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Cell 20 , — Due to their germline expression, disruption of PIWI in multiple species has varying implication for reproduction. Thus, Stellate derepression caused by the lack of Su Ste piRNAs might contribute to sterility of interspecies hybrids.

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Discovery of Potential piRNAs from Next Generation Sequences of the Sexually Mature Porcine Testes

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Ohara, T. A minority of hybrids maintained wild-type array of premeiotic germ cells in the testes, but in them harmful Stellate genes were derepressed due to the absence of Su Ste piRNAs, and meiotic failures were observed.
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Open PDF Get citation. Previous studies showed that interspecies hybrids have a unique genetic background that is not simply an additive combination of the two parental genomes reviewed in 59

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Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes

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In contrast, the nt oocyte piRNAs maintained a relatively stable level in the two-cell and later stages, implying that they may play specific roles in genome reprogramming during early embryonic development, warranting further investigation. List of transposable elements and the related repeat sequences which generate small Meet for sex Pirna. Genet Mol Res14 429 Dec The rules that govern the recognition of proper targets and discriminate against off-target effects are not clearly understood. Gene, 07 Mar