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Whereas one large study did not find any effect of sex on pharmacokinetic parameters, 9 , another showed that plasma LPV concentration-ratios were significantly higher in females compared to males, and this difference was explained by lower weight in females.

Major exclusion criteria were pregnancy, concomitant use of a second active protease inhibitor, a non-nucleoside reverse meet for sex Kakuda inhibitor or concomitant use of medications known to interact with LPV or RTV.

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The higher median RTV concentrations in women on the tablet formulation were most evident in the subset receiving TDF.

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Kakuda, Miyagi, Japan Latitude:, Longitude: 332.211245559

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